Fri Oct 07 2022

61 articles - From Friday Sep 30 2022 to Friday Oct 07 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Adult survivors of a first primary invasive cancer had increased risk for cardiovascular disease.

2022; 80:22-32. 35772913.

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First-Line Therapy for Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists : A Cost-Effectiveness Study.

As first-line agents, SGLT2 inhibitors and GLP1 receptor agonists would improve type 2 diabetes outcomes, but their costs would need to fall by at least 70% to be cost-effective. Primary funding source American Diabetes Association.

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Heterogeneity in Obesity Prevalence Among Asian American Adults.

Substantial heterogeneity in obesity prevalence exists among Asian American subgroups in the United States. Future studies and public health efforts should consider this heterogeneity. Primary funding source National Heart, Lung, and Blood Institute.

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In active Crohn disease, risankizumab increased clinical remission and endoscopic response at 12 wk.

2022; 399:2015-30. 35644154.

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In active UC, upadacitinib induced and maintained remission.

2022; 399:2113-28. 35644166.

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In adults hospitalized with COVID-19, adding baricitinib vs. dexamethasone to remdesivir did not differ for MV-free survival.

2022; 10:888-99. 35617986.

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In adults with obesity without diabetes, adding tirzepatide to a lifestyle intervention increased weight loss at 72 wk.

2022; 387:205-16. 35658024.

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In fibromyalgia, amitriptyline is comparable to FDA-approved drugs for symptoms and acceptability.

2022; 5:e2212939. 35587348.

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In HFpEF, the benefit of empagliflozin on a composite of CV death or HF hospitalization at 26 mo did not vary by diabetes status.

2022; 146:676-86. 35762322.

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In migraine with previous treatment failures, eptinezumab safely reduced migraine days at 1 to 12 wk.

2022; 21:597-607. 35716692.

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In patients with high bleeding risk, 1 vs. =3 mo of DAPT after complex or noncomplex PCI did not differ for clinical events.

2022:43:3100-14. 35580836.

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The Fall of the Nation's First Gender-Affirming Surgery Clinic.

The study that informed the GAS ban was preferentially funded in keeping with the political economy of biomedical research. This article presents a spatial argument for how the closure of the nation's first GAS clinic was not based in empirical data alone but was manipulated to fuel political and institutional agendas.

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USPSTF recommends against beta carotene or vitamin E supplements for preventing CVD or cancer in adults.

2022; 327:2326-33. 35727271.

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Lancet

Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial.

Interpretation An AI-guided targeted screening approach that leverages existing clinical data increased the yield for atrial fibrillation detection and could improve the effectiveness of atrial fibrillation screening. Funding Mayo Clinic Robert D and Patricia E Kern Center for the Science of Health Care Delivery.

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Flexible resources and experiences of racism among a multi-ethnic adolescent population in Aotearoa, New Zealand: an intersectional analysis of health and socioeconomic inequities using survey data.

In multi-ethnic western societies, anti-racist interventions and policies must address both structural deprivation and associated intergenerational mobility and colourism (ie, implicit and explicit bias against non-White youth). Funding Health Research Council of New Zealand.

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N Engl J Med

Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes.

Among participants with type 1 diabetes and high glycated hemoglobin levels, the use of intermittently scanned continuous glucose monitoring with optional alarms for high and low blood glucose levels resulted in significantly lower glycated hemoglobin levels than levels monitored by fingerstick testing. (Funded by Diabetes UK and others; FLASH-UK ClinicalTrials.gov number, NCT03815006.).

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Trial of Intravenous Immune Globulin in Dermatomyositis.

In this 16-week trial involving adults with dermatomyositis, the percentage of patients with a response of at least minimal improvement based on a composite score of disease activity was significantly greater among those who received IVIG than among those who received placebo. IVIG was associated with adverse events, including thromboembolism. (Funded by Octapharma Pharmazeutika; ProDERM ClinicalTrials.gov number, NCT02728752.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Current best practice for bladder cancer: a narrative review of diagnostics and treatments.

We discuss the current role of radiotherapy, surgical management of non-muscle-invasive and muscle-invasive disease, highlight the challenges of treatment of metastatic bladder cancer, and discuss the latest developments in systemic therapy. This Seminar is intended to provide physicians with knowledge of current issues in bladder cancer.

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Offline: Women, life, freedom-and Twitter.

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Polio eradication: falling at the final hurdle?

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N Engl J Med

Audio Interview: Infectious Disease in Africa.

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Intravenous Immune Globulin Therapy in Dermatomyositis.

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Prevention of and Emergency Response to Drowning.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

A Cautionary Tale: The Doomed Gender Identity Clinic at Johns Hopkins Hospital.

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Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States.

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Summary for Patients: Prevalence of Obesity in Asian American Adults.

Pubmed   Journal   ReadQx 

Using Body Mass Index to Identify and Address Obesity in Asian Americans: One Size Does Not Fit All.

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Lancet

Addressing the human costs and consequences of the Pakistan flood disaster.

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Coloniality and racism impacts the health of young people.

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Fragile X-associated tremor or ataxia syndrome in a patient with difficulty walking, falls, a tremor, and erectile dysfunction.

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Global Fund secures $14·3 billion from donors.

Pubmed   Journal   ReadQx   PMC

Lasker Awards 2022.

Pubmed   Journal   ReadQx 

Professor Dame Valerie Beral.

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Rhea Boyd: paediatrician advocating for health equity.

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N Engl J Med

A Grim New Reality - Intimate-Partner Violence after Dobbs and Bruen.

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Atrial Fibrillation and Catheter Ablation.

Pubmed   Journal   ReadQx 

Circulating Poliovirus in New York - New Instance of an Old Problem.

Pubmed   Journal   ReadQx 

Erythema Ab Igne.

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From the Eyeball Test to the Algorithm - Quality of Life, Disability Status, and Clinical Decision Making in Surgery.

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Gun Violence in the United States.

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Public Carry versus Public Health - The Harms to Come from the Supreme Court's Decision in Bruen.

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The Macro-Harm of Micro-Geography.

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Thinking Outside the Heart.

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Toxic Megacolon Due to Fulminant Clostridioides difficile Infection.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Lancet

A healthy future for children and adolescents - Authors' reply.

Pubmed   Journal   ReadQx 

A healthy future for children and adolescents.

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A healthy future for children and adolescents.

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A healthy future for children and adolescents.

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A healthy future for children and adolescents.

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A healthy future for children and adolescents.

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Overcoming challenges en route to polio eradication.

Pubmed   Journal   ReadQx 

N Engl J Med

Accountable Care's Reach in Medicare.

Pubmed   Journal   ReadQx 

Accountable Care's Reach in Medicare. Reply.

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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.

Pubmed   Journal   ReadQx 

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.

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Obesity in Pregnancy.

Pubmed   Journal   ReadQx 

Obesity in Pregnancy.

Pubmed   Journal   ReadQx 

Obesity in Pregnancy. Reply.

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Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B.

Pubmed   Journal   ReadQx 

Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B. Reply.

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Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants.

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